Cannabidiol (CBD) oil has become the hot cool product in states that have legalized medical marijuana. The non-intoxicating marijuana extract is being credited with helping treat a host of medical conditions — everything from epileptic seizures to anxiety to inflammation to sleeplessness. But experts say the evidence is scant for many of these touted benefits.
Worse, CBD is being produced with no regulation, resulting in products which vary widely in quality, said Marcel Bonn-Miller, an adjunct assistant professor of psychology in psychiatry at the University of Pennsylvania School of Medicine. “It really is the Wild West,” Bonn-Miller said. “Joe Bob who starts up a CBD company could say whatever the hell he wants on a label and sell it to people.”
Cannabidiol is extracted from the flowers and buds of marijuana or hemp plants. It will not produce intoxication; marijuana’s “high” is caused by the chemical tetrahydrocannabinol (THC). CBD oil is legal in 30 states where medicinal and/or recreational marijuana is legal, according to Governing magazine.
Seventeen additional states have CBD-specific laws on the books, according to Prevention magazine. Those are Alabama, Georgia, Indiana, Iowa, Kentucky, Mississippi, Missouri, N . C ., Oklahoma, South Carolina, South Dakota, Tennessee, Texas, Utah, Virginia, Wisconsin and Wyoming.
Strong Evidence for Treating Epilepsy – Just one purported use for more information at healthbenefitscannabidiol.com, to take care of epilepsy, has significant scientific evidence supporting it. Last month, a U.S. Food and Drug Administration advisory panel unanimously recommended approval from the CBD medication Epidiolex to treat two rare types of childhood epilepsy. “That’s really the only area in which the evidence has risen to the stage where the FDA has said this can be acceptable to approve a brand new drug,” said Timothy Welty, chair in the department of clinical sciences at Drake University’s College of Pharmacy and Health Sciences, in Des Moines, Iowa.
Throughout CBD’s potential uses, there is certainly simply not enough evidence to produce a firm conclusion. For example, some human clinical trials advise that CBD could be good at treating symptoms of anxiety, particularly social anxiety, Bonn-Miller said. This is the potential use for CBD with all the most evidence after usefulness in epilepsy, but “there’s a decent gap between the two,” he said. “There have been clinical studies in adults, but a lot smaller compared to the epilepsy studies that have been done in kids,” Bonn-Miller said. CBD’s usefulness being an anti-inflammatory medication is the following most promising, but those results come mostly from animal studies, experts said.
The Majority Of Uses Largely Unproven – All of those other potential uses — being an antipsychotic, antidepressant or sleep aid “have got all been studied in animals, with only a couple of examples of studies in humans,” Bonn-Miller said. And Welty said the studies which have featured humans for such other CBD uses have either been case reports or studies that did not compare results against a control group that did not use the oil. “There’s no control, so it’s basically how do you know if we’re working with the actual effect from the drug or just simply a placebo effect because somebody thinks they’ve been given a drug that might be beneficial?” Welty said. There are concerns about both the caliber of CBD oil being produced along with its potential side effects, professionals added.
Absence of Regulation Also Concerning – Because of the legally murky nature of marijuana, the FDA has not stepped in to regulate items like CBD oil, Bonn-Miller said. States are struggling to set regulations in position, but they don’t possess the deep pockets of the federal government. Meanwhile, a 2017 study led by Bonn-Miller learned that nearly 7 of 10 CBD products didn’t contain the amount of marijuana extract promised on the label. Nearly 43 percent from the products contained not enough CBD, while about 26 percent cptgdg a lot of, Bonn-Miller said.
“CBD is sort of a tricky drug because it’s not very well absorbed orally,” Welty explained. “Less than 20 % in the drug is absorbed orally. If it isn’t made in the right way, you possibly will not be getting much drug into your systemic circulation.” Worse, about 1 in five CBD products contained the intoxicating pot chemical THC, Bonn-Miller and his awesome colleagues found.
“That’s an issue because THC can increase anxiety. It could actually make seizures worse. These are the sorts of things you have to be careful about,” Bonn-Miller said. “Should I were a consumer, purchasing it personally or my kid, I would like to test it so that I knew exactly what it actually had within it, because I couldn’t trust what was on the label,” Bonn-Miller concluded.
Potential Interactions Along With Other Meds – Studies on CBD also have raised concerns about possible interactions along with other drugs. For example, epilepsy studies found that “there have been very clearly increases within the blood degrees of a few other anti-epileptic drugs whenever people were on CBD,” Welty said.